The Impact of Body Weight Change on Liver Histology in Metabolic Dysfunction-Associated Steatotic Liver Disease Across Various Histological Endpoints: A Systematic Review and Meta-Analysis
Even modest observed weight loss is associated with MASH resolution. MASH resolution and ≥1-stage fibrosis improvement are not affected by body mass index, type 2 diabetes mellitus, or Hispanic/Latino ethnicity, reinforcing the importance of lifestyle interventions across populations. The proportions observed serve as benchmark estimates of histological response for future clinical trial design.
Authors
- Dujinthan Jayabalan (ORCID: https://orcid.org/0000-0001-9722-661X)
- George Garas (ORCID: https://orcid.org/0000-0001-6732-6986)
- J Chandra (ORCID: https://orcid.org/0009-0000-2741-894X)
- Leon Anton Adams (ORCID: https://orcid.org/0000-0002-3968-7909)
- Sugam Dhakal (ORCID: https://orcid.org/0000-0002-9813-9881)
- Daniel Fasser (ORCID: https://orcid.org/0000-0003-0375-728X)
- Gary P Jeffrey
- Luis Calzadilla-Bertot
Institutions
- The University of Western Australia (AU)
- Fiona Stanley Hospital (AU)
- Sir Charles Gairdner Hospital (AU)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Biomedicina de Sevilla (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.14309/ajg.0000000000003918
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00