Multi-omics identifies lipid accumulation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome cell lines: a case-control study
LCLs generated from circulating B cells from people with ME/CFS show accumulation of lipids, skewed lipid profiles and altered activity of related metabolic enzymes such as PTDSS1. These findings will inform future hypothesis-driven studies of primary lymphoid cell populations from people with ME/CFS to dissect specific immunometabolic mechanisms that may be involved in the syndrome, particularly relating to intersections between lipid abnormalities and potential effects on immune cell effector functions.
Authors
- Darren J. Creek (ORCID: https://orcid.org/0000-0001-7497-7082)
- Paige K. Smith (ORCID: https://orcid.org/0000-0002-0750-0468)
- T. Esmaili (ORCID: https://orcid.org/0000-0002-3014-9581)
- Claire Y. Allan (ORCID: https://orcid.org/0000-0002-4113-3163)
- P Fisher
- Sarah J. Annesley (ORCID: https://orcid.org/0000-0002-7604-3985)
- Oana Sanislav (ORCID: https://orcid.org/0000-0002-9335-3344)
- Christopher W. Armstrong (ORCID: https://orcid.org/0000-0002-5964-5618)
- Daniel Missailidis
- Dovile Anderson
Institutions
- The University of Melbourne (AU)
- La Trobe University (AU)
- Monash Health (AU)
- Agriculture and Food (AU)
- Monash Institute of Medical Research (AU)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s12967-025-07620-x
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00