The role of gene polymorphisms in the occurrence of gastroesophageal reflux disease: A systematic review and meta-analysis of genetic association studies
The findings support a robust association between GNB3 rs5443 C > T and susceptibility to GERD-like symptom phenotypes, suggesting a potential genetic predisposition. Additional large, well-characterized studies using standardized GERD definitions are needed to validate these results and elucidate the broader genetic landscape of the disease.
Authors
- Alexandra Argyrou
- Stamatina Vogli (ORCID: https://orcid.org/0000-0003-4944-2611)
- Ioannis Karniadakis (ORCID: https://orcid.org/0000-0001-9924-0044)
- Elisavet Michailidou
- Stavros P. Papadakos
- Jannis Vlachogiannakos
Institutions
- St George’s University Hospitals NHS Foundation Trust (GB)
- Laiko General Hospital of Athens (GR)
- Metaxa Hospital (GR)
Publication Details
- Journal
- Digestive and Liver Disease
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.dld.2025.12.014
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00