19 01 Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

High-Grade Serous Ovarian Carcinoma (HGSC) represents the most lethal gynecological malignancy, with 5year survival rates below 30% for advanced stages. A subset of HGSC tumors exhibit estrogen receptor (ER)expression with luminal characteristics (HGSC-ER-like), creating a unique metabolic and spatial architecturedistinct from basal-type HGSC. Understanding the mechanistic basis of this tumor’s extreme adaptabilityrequires integration of multiple biological scales: from tissue-level equilibrium to subcellular organellar dynamics.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-07
DOI
https://doi.org/10.5281/zenodo.18167862
Primary Topic
PARP inhibition in cancer therapy
Type
article
Field-Weighted Citation Impact
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article

19 01 Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
PARP inhibition in cancer therapy
article

19 01 Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

Ionut Alexandru Stefan
article en

Abstract

High-Grade Serous Ovarian Carcinoma (HGSC) represents the most lethal gynecological malignancy, with 5year survival rates below 30% for advanced stages. A subset of HGSC tumors exhibit estrogen receptor (ER)expression with luminal characteristics (HGSC-ER-like), creating a unique metabolic and spatial architecturedistinct from basal-type HGSC. Understanding the mechanistic basis of this tumor’s extreme adaptabilityrequires integration of multiple biological scales: from tissue-level equilibrium to subcellular organellar dynamics.

Zenodo (CERN European Organization for Nuclear Research)
Good health and well-being
Openalex Percentile: Top 94%
PARP inhibition in cancer therapy
DOIOpen Access PDFOpenAlex
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19 01 Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS