Integrative multi-omics and radiogenomic profiling decodes NNK-related tumor remodeling and prognostic stratification in pancreatic cancer
NNK is associated with a malignant transcriptional program characterized by epithelial remodeling, stromal interaction, and immune suppression. These molecular features can be captured non-invasively through CT-based radiomics. The NNK-related ITGA3-associated radiomics (NIR) score provides a practical tool for preoperative risk stratification in PC and offers a bridge linking environmental carcinogen exposure with tumor imaging phenotypes.
Authors
- Hanxiao Li (ORCID: https://orcid.org/0000-0001-6732-6417)
- Junjian Shen
- Qiying Tang
- Jun Zhou (ORCID: https://orcid.org/0000-0001-8560-8557)
- Jingcheng Huang
- Huaping Sun
- Zongyu Xie (ORCID: https://orcid.org/0000-0003-1359-5157)
- M S Zeng
- Minping Hong
- Qiuyang Zhu
- Jianbo Li
- Yaolin Xu
- Yuan Fang
Institutions
- Zhejiang Chinese Medical University (CN)
- Goodyear (United Kingdom) (GB)
- North University of China (CN)
- Fudan University (CN)
- Jiaxing University (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- First Hospital of Jiaxing (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1097/js9.0000000000004732
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00