Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial

The current Pediatric Surviving Sepsis Guidelines do not provide definitive recommendations regarding the use of corticosteroids in pediatric septic shock. Our study will be the first pediatric trial that is adequately powered to assess both potential benefits and adverse effects of corticosteroids in patients with septic shock. The results of this study will provide definitive data upon which to base future recommendations for corticosteroid administration in pediatric septic shock.

Authors

Institutions

Publication Details

Journal
Pediatric Critical Care Medicine
Published
2025-11-26
DOI
https://doi.org/10.1097/pcc.0000000000003872
Citations
2
Primary Topic
Adrenal Hormones and Disorders
Type
article
Field-Weighted Citation Impact
2.59
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial

David Wypij, Kerry Coughlin-Wells, Jan Hau Lee, Jerry J. Zimmerman et al.
2 citations
Pediatric Critical Care Medicine
Adrenal Hormones and Disorders
2.59
article

Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial

David Wypij, Kerry Coughlin-Wells, Jan Hau Lee, Jerry J. Zimmerman, T.G. Ramsay, Karen W. Choong, M. Agus, Kusum Menon, R. Scott Watson, Dayre McNally, Yasser Kazzaz, for the Stress Hydrocortisone in Pediatric Septic Shock (SHIPSS) Study Investigators, Canadian Critical Care Trials Group, and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network, Katie O’Hearn, Mihir R. Atreya
article en
2 citations

Abstract

The current Pediatric Surviving Sepsis Guidelines do not provide definitive recommendations regarding the use of corticosteroids in pediatric septic shock. Our study will be the first pediatric trial that is adequately powered to assess both potential benefits and adverse effects of corticosteroids in patients with septic shock. The results of this study will provide definitive data upon which to base future recommendations for corticosteroid administration in pediatric septic shock.

Pediatric Critical Care MedicineVol. 27(1)
Cincinnati Children's Hospital Medical Center (US), Boston Children's Hospital (US), Harvard University (US), King Saud bin Abdulaziz University for Health Sciences (SA), Ottawa Hospital (CA), King Abdullah International Medical Research Center (SA), SingHealth Duke-NUS Academic Medical Centre (SG), Seattle Children's Hospital (US), KK Women's and Children's Hospital (SG), Impact (CA), Ottawa Hospital Research Institute (CA), University of Cincinnati Medical Center (US), McMaster University (CA)
Good health and well-being
Openalex Percentile: Top 8%
Adrenal Hormones and Disorders
2.59
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Stress Hydrocortisone in Pediatric Septic Shock: Protocol for a Pragmatic, Multicenter, International, Randomized, Double-Blinded, Placebo-Controlled Interventional Trial — David Wypij, Kerry Coughlin-Wells, et al. · Pediatric Critical Care Medicine (2025) | TGRS Research Map | TGRS