Development of a novel prognostic model based on TRPM4-Induced sodium overload–mediated cell death in kidney cancer
This study systematically unveils the tumor-suppressive role of TRPM4 in ccRCC and innovatively establishes the NECSO Score as a robust prognostic model. This score not only accurately predicts patient outcomes but also illuminates the potential link between sodium ion homeostasis and the tumor immune landscape. Targeting TRPM4 and NECSO may represent a promising therapeutic avenue for ccRCC.
Authors
- Longchao Zhang
- Changwen Zhang
- Bin Chen
- Wei Wang
- Duo Zhao
- Zijun Zhou
- E. Du
Institutions
- Second Hospital of Tianjin Medical University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fcell.2025.1755318
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00