Amelioration of polycystic ovarian morphology by Tokishakuyakusan in a PCOS rat model: association with bone morphogenetic protein 4
TSS ameliorated PCOS-like ovarian histopathology in prenatally DHT-treated rats and enhanced progesterone production by upregulating <i>Star</i> expression in GCs, accompanied by reduced BMP4 expression. These findings suggest that TSS may improve irregular estrous cycles and ovarian morphology in PCOS through the regulation of BMP4 signaling.
Authors
- Mako Ueda
- Reina Sonehara (ORCID: https://orcid.org/0009-0004-2807-2177)
- Tomoko Nakamura (ORCID: https://orcid.org/0000-0001-5987-4384)
- Jiali Ruan (ORCID: https://orcid.org/0000-0003-0994-3518)
- Satoko Osuka (ORCID: https://orcid.org/0000-0002-4430-7982)
- Atsushi Yabuki
- Ayako Muraoka (ORCID: https://orcid.org/0000-0003-2203-0844)
- Hiroaki Kajiyama (ORCID: https://orcid.org/0000-0003-0493-1825)
- Yohei Tokita (ORCID: https://orcid.org/0000-0001-5762-0065)
- Tomomi Seki (ORCID: https://orcid.org/0009-0008-9317-8233)
- Bayasula
- Takehiko Takeda
- Miwa Nahata
- Naoki Fujitsuka
Institutions
- Aichi Medical University (JP)
- Tsumura Research Institute (Japan) (JP)
- Tsumura (Japan) (JP)
- Nagoya University (JP)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fendo.2025.1649124
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00