Allosensitization From Blood Transfusion in Pediatric Solid Organ Transplant Candidates: Impact of Irradiation
The number of pRBC transfusions remains the strongest modifiable risk factor for pre-transplant allosensitization in pediatric SOT candidates. Irradiation of pRBC did not significantly reduce the risk of transfusion-associated allosensitization in this population. IVIG may have a protective effect and should be further evaluated in a future, better powered study.
Authors
- Paul Brailey (ORCID: https://orcid.org/0000-0002-3306-6132)
- Charles D. Varnell (ORCID: https://orcid.org/0000-0002-0409-3799)
- Stephanie Kinney (ORCID: https://orcid.org/0000-0002-5014-3435)
- Teresa Ambrosino
- Corinne M. Hite (ORCID: https://orcid.org/0009-0004-8883-7776)
- Kyle Merrill
- Don Hayes
- Samuel A. Kocoshis
- David K. Hooper
- Alexander G. Miethke
- Clifford Chin
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- University of Iowa Health Care (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Pediatric Transplantation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1111/petr.70265
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00