Antigen binding triggers long-range conformational changes in monoclonal antibodies
These findings suggest that antigen engagement initiates a cascade of coordinated motions that reshape the mAb architecture and regulate its interaction with the immune receptors, offering new insights for the design of functionally optimized therapeutic antibodies.
Authors
- Wolf Palinsky
- Omar Ben Mariem
- Simona Saporiti (ORCID: https://orcid.org/0000-0002-2096-1066)
- Fabio Centola (ORCID: https://orcid.org/0000-0002-3994-3773)
- Mara Rossi (ORCID: https://orcid.org/0000-0002-4195-9897)
- Davide Bianchi
- Ivano Eberini
Institutions
- University of Milan (IT)
- Merck Serono S.A. (Switzerland) (CH)
- Merck Serono S.p.A. (Italy) (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1680199
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00