Splenic accumulation of intact Plasmodium ovale sensu lato-infected red blood cells in a patient presenting with splenic rupture
A 35-year-old man had splenic rupture just after starting antimalarial treatment with atovaquone-proguanil followed by artesunate for acute Plasmodium ovale sensu lato infection. Spleen histology showed a 10-fold accumulation of intact P. ovale s.l.-infected erythrocytes in the spleen parenchyma compared to the general circulation. Infected erythrocytes also accumulated in small extra-splenic blood vessels, suggesting cytoadherence.
Authors
- Sandrine Houzé (ORCID: https://orcid.org/0000-0001-9016-3847)
- Steven Kho (ORCID: https://orcid.org/0000-0003-0926-8049)
- Abdoulaye SISSOKO
- Paul Henri Consigny
- Valentin Joste
- David Hardy
- Ghania Benabdelmoumen
- Oula Itani
- Pierre Buffet
- Moussa Sylla
- Nicholas M. Anstey
Institutions
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Charles Darwin University (AU)
- Menzies School of Health Research (AU)
- Sorbonne Paris Cité (FR)
- Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Lux Research (United States) (US)
- Institut de Recherche pour le Développement (FR)
- Imation (United States) (US)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1371/journal.pntd.0013897
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00