CRISPR/Cas12a-RCA enables ultrasensitive detection of circulating free DNA for noninvasive diagnosis of echinococcosis
The optimized one-pot CRISPR/Cas12a-RCA system enables rapid and ultrasensitive detection of pan-Echinococcus cfDNA, providing a cost-effective and highly accurate solution for the primary screening of echinococcosis.
Authors
- Lanmin Liu
- A Jide
- Yumei Zhang (ORCID: https://orcid.org/0000-0002-1985-2532)
- Lei Jiang
- Chunhua Cao
- Jianwu Zhou
- Peng Cheng
- Li Ma
- Yuqi Li
- Jideng Ma
- Xiangren A
- Zian Li
- Zhiyuan Li
- Run Liang
Institutions
- Qinghai University (CN)
- Institute of Tibetan Plateau Research (CN)
- Qinghai Provincial Peoples Hospital (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1371/journal.pntd.0013069
- Citations
- 2
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 44.47