Clobazam in Adult Drug-Resistant Epilepsy: Excellent Long-Term Retention and Potential Synergy with Neuromodulation

Among adults with DRE who successfully tolerate at least six months of clobazam therapy, long-term retention is excellent (95%), and sustained efficacy is maintained. These findings provide valuable insight into long-term outcomes, specifically in treatment-tolerant patients. Furthermore, combination therapy with neuromodulation demonstrates potential complementarity. These findings provide valuable insight into long-term outcomes in treatment-tolerant patients and suggest that careful ongoing management optimizes clinical outcomes in adult DRE.