Associations between metabolic syndrome and regional brain iron depositions and cognitive function in middle‐aged and older adults: A two multinational cohort study

Iron deposition in deep gray matter nuclei was found in patients with metabolic syndrome (Mets) in both UK Biobank (UKB) and Jinan cohort. Iron deposition in the deep gray matter nuclei of Mets in UKB was mainly related to hyperglycemia and elevated triglycerides among metabolic risk factors. The UKB longitudinal study found that the susceptibility values of the caudate nucleus and putamen of Mets patients increased significantly with age compared to healthy controls. Patients with Mets exhibited poorer cognitive function, which was closely associated with iron deposition in the right caudate nucleus in the Jinan cohort. The association between iron deposition and cognition was more concentrated in the elderly, smokers and drinkers, and those with low years of education.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2026-01-01
DOI
https://doi.org/10.1002/alz.71080
Primary Topic
Iron Metabolism and Disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Associations between metabolic syndrome and regional brain iron depositions and cognitive function in middle‐aged and older adults: A two multinational cohort study

Yiwen Chen, Meng Li, C LIANG, Yuanyuan Wang et al.
Alzheimer s & Dementia
Iron Metabolism and Disorders
article

Associations between metabolic syndrome and regional brain iron depositions and cognitive function in middle‐aged and older adults: A two multinational cohort study

Yiwen Chen, Meng Li, C LIANG, Yuanyuan Wang, Lingfei Guo, Pengcheng Liang, Qihao Zhang, Na Wang, L Yang, Zhenyu Cheng, Xinyue Zhang
article en

Abstract

Iron deposition in deep gray matter nuclei was found in patients with metabolic syndrome (Mets) in both UK Biobank (UKB) and Jinan cohort. Iron deposition in the deep gray matter nuclei of Mets in UKB was mainly related to hyperglycemia and elevated triglycerides among metabolic risk factors. The UKB longitudinal study found that the susceptibility values of the caudate nucleus and putamen of Mets patients increased significantly with age compared to healthy controls. Patients with Mets exhibited poorer cognitive function, which was closely associated with iron deposition in the right caudate nucleus in the Jinan cohort. The association between iron deposition and cognition was more concentrated in the elderly, smokers and drinkers, and those with low years of education.

Alzheimer s & DementiaVol. 22(1)
Shandong University of Aeronautics (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Cornell University (US), Peking Union Medical College Hospital (CN), Jinan Maternity And Care Hospital (CN), Shandong Provincial Hospital (CN), Jena University Hospital (DE), Shandong Maternal and Child Health Hospital (CN), Shandong First Medical University (CN), Friedrich Schiller University Jena (DE)
Natural Science Foundation of Shandong Province, Medical and Health Science and Technology Development Project of Shandong Province
Openalex Percentile: Top 94%
Iron Metabolism and Disorders
DOIOpen Access PDFOpenAlex
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