Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages
The identified clonotypes are novel therapeutic targets to treat IBD, for example, through targeted depletion. By identifying antigens recognized by these T cells, a better understanding of the etiopathology of IBD, particularly CD, can be obtained.
Authors
- Gøri Perminow (ORCID: https://orcid.org/0000-0002-4158-372X)
- Harlan Robins (ORCID: https://orcid.org/0000-0001-5225-7076)
- M H Vatn (ORCID: https://orcid.org/0000-0002-1179-4550)
- Damon May (ORCID: https://orcid.org/0000-0001-6902-3153)
- Hesham Elabd
- B. Bokemeyer
- Johannes R. Hov (ORCID: https://orcid.org/0000-0002-5900-8096)
- Valeriia Kriukova (ORCID: https://orcid.org/0000-0002-5168-6511)
- Andre Franke
- Érika Endo Kokubun
- Bryan Bryan Howie
- Stefan Schreiber
- Svend Andersen
- May-Bente Bengtson
- IBSEN-III study group
- Mitchell Pesesky
- Bjørn Moum
- Vendel A. Kristensen
- Aya K. H. Mahdy
- Christine Olbjørn
- Jonas Halfvarson
- Marte Lie Høivik
- Jørgen Jahnsen
- Petr Ricanek
Institutions
- Oslo University Hospital (NO)
- Lithuanian University of Health Sciences (LT)
- University of Oslo (NO)
- Örebro University (SE)
- Akershus University Hospital (NO)
- Sykehuset i Vestfold (NO)
- Lovisenberg Diakonale Høgskole (NO)
- Adaptive Biotechnologies (United States) (US)
- University Hospital Schleswig-Holstein (DE)
- Crohn's and Colitis UK (GB)
- Østfold Hospital Trust (NO)
- University of Lübeck (DE)
Publication Details
- Journal
- Genome Medicine
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s13073-025-01575-w
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00