Identifying early changes in imaging, plasma, and digital cognitive biomarkers that correspond to Alzheimer's disease pathology in the presence of autopsy‐confirmed co‐pathologies
Amyloid beta-positron emission tomography (Aβ-PET), tau-PET imaging, and plasma tau phosphorylated at threonine 217 (p-tau217) correlate with ABC scores Correlations were larger for Aβ-PET distribution volume ratio (DVR) and tau-PET standardized uptake volume ratio (SUVR; composite reference, partial volume correction [PVC]) Digital Clock Drawing Test latency features correlate with A- and Cscores Standard cognitive measures mostly did not correlate with ABC scores Plasma glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) biomarkers did not correlate with ABC scores.
Authors
- Pia Kivisäkk Webb
- Brian C. Healy
- Dana L. Penney (ORCID: https://orcid.org/0000-0003-3105-6974)
- R. N. Davis
- Emma G. Thibault (ORCID: https://orcid.org/0000-0002-7873-742X)
- Charles D. Chen
- Alexandra Melloni (ORCID: https://orcid.org/0000-0002-0657-5919)
- Julie Price
- Hyun‐Sik Yang
- Jessie Fanglu Fu
- Michelle E. Farrell
- Steven Arnold
- Jasmeer Chhatwal
- Dorene Rentz
- Stephanie Schultz
- Keith A. Johnson
- Reisa A. Sperling
- Cinthya Aguero
- Teresa Gomez‐Isla
- Jean‐Pierre Bellier
Institutions
- Tufts University (US)
- Brigham and Women's Hospital (US)
- Lahey Hospital and Medical Center (US)
- University of Massachusetts Chan Medical School (US)
- Massachusetts General Hospital (US)
- Lahey Medical Center (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1002/alz.71092
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts General Hospital
- Meso Scale Diagnostics
- National Institutes of Health
- Air Force Office of Scientific Research