IL-6, calcium, salivary amylase activity and cortisol as a salivary biomarker-combination associated with obesity: a pilot study
In conclusion, this study highlights IL-6, Ca<sup>2+</sup>, sAA, and cortisol as a potential salivary biomarker-combination associated with obesity warranting further investigation. The observed changes in the salivary biomarker levels of the obese group may reflect underlying metabolic dysregulations, highlighting the advantage of a multi-biomarker approach to better capture early metabolic and inflammatory processes associated with obesity. To further validate these findings, large clinical studies with diverse, well-matched cohorts, as well as longitudinal studies, are needed.
Authors
- F. J. Bikker
- L. K. Van Nieukerken
- R. H. H. Pieters
- V. E. A. Gerdes
- H. Al Habobe
- K. Nazmi
- E. B. Haverkort
Institutions
- University of Applied Sciences Utrecht (NL)
- Utrecht University (NL)
- Academic Center for Dentistry Amsterdam (NL)
- Spaarne Ziekenhuis (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Frontiers in Dental Medicine
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fdmed.2025.1725865
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health~Holland
- Universiteit Utrecht