Neratinib, a Clinical Drug Treating Breast Cancer, Protects Against Vascular Inflammation and Atherosclerosis

Taken together, these findings support the concept that neratinib could be tested as a repurposed drug for vascular inflammation and atherosclerosis, thereby streamlining efforts to translate preclinical discoveries to clinical testing in humans.

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Publication Details

Journal
Circulation Research
Published
2026-01-09
DOI
https://doi.org/10.1161/circresaha.125.326508
Primary Topic
Kruppel-like factors research
Type
article
Field-Weighted Citation Impact
0.00
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article

Neratinib, a Clinical Drug Treating Breast Cancer, Protects Against Vascular Inflammation and Atherosclerosis

S. Xu, He Cy, Fan-shun Zhang, Jiang-Yun Luo et al.
Circulation Research
Kruppel-like factors research
article

Neratinib, a Clinical Drug Treating Breast Cancer, Protects Against Vascular Inflammation and Atherosclerosis

S. Xu, He Cy, Fan-shun Zhang, Jiang-Yun Luo, Xiumei Wu, Danielle Kamato, Ruixue Leng, Jianping Weng
article en

Abstract

Taken together, these findings support the concept that neratinib could be tested as a repurposed drug for vascular inflammation and atherosclerosis, thereby streamlining efforts to translate preclinical discoveries to clinical testing in humans.

Circulation ResearchVol. 138(4)
Griffith University (AU), University of Science and Technology of China (CN), Bengbu Medical College (CN), Anhui Medical University (CN), Hefei Institutes of Physical Science (CN), Anhui Provincial Hospital (CN), Guangdong Academy of Medical Sciences (CN), First Affiliated Hospital Zhejiang University (CN)
Good health and well-being
Openalex Percentile: Top 93%
Kruppel-like factors research
DOISourceOpenAlex
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Neratinib, a Clinical Drug Treating Breast Cancer, Protects Against Vascular Inflammation and Atherosclerosis — S. Xu, He Cy, et al. · Circulation Research (2026) | TGRS Research Map | TGRS