Cervical Vertebral Arteriovenous Fistula Presenting as Progressive Spastic Quadriparesis in a Young Adult with Neurofibromatosis Type 1

Neurofibromatosis type 1 (NF1) is a common autosomal dominant neurocutaneous disorder with multisystem involvement. Although cutaneous and neural manifestations are frequent, vascular complications are relatively rare and often under-recognized. Spinal arteriovenous fistulas (AVFs) are an uncommon but important vascular manifestation of NF1 and may lead to progressive myelopathy due to venous hypertension and cord compression. We report a case of a 30-year-old male soldier presenting with gradually progressive spastic quadriparesis and sensory impairment caused by a cervical vertebral arteriovenous fistula associated with NF1. Successful endovascular embolization resulted in complete obliteration of the fistula and neurological stabilization. This case highlights the importance of early suspicion, detailed neuroimaging, and timely intervention in potentially reversible causes of myelopathy.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-08
DOI
https://doi.org/10.5281/zenodo.18182731
Primary Topic
Vascular Malformations Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Cervical Vertebral Arteriovenous Fistula Presenting as Progressive Spastic Quadriparesis in a Young Adult with Neurofibromatosis Type 1

Kyaw Zaw Lynn1*, Myint Thein Naing2 Aung Moe Myint3, Kyaw Zaya4, Ohnmar Saw5 & Nwe Nwe Win6
Zenodo (CERN European Organization for Nuclear Research)
Vascular Malformations Diagnosis and Treatment
article

Cervical Vertebral Arteriovenous Fistula Presenting as Progressive Spastic Quadriparesis in a Young Adult with Neurofibromatosis Type 1

Kyaw Zaw Lynn1*, Myint Thein Naing2 Aung Moe Myint3, Kyaw Zaya4, Ohnmar Saw5 & Nwe Nwe Win6
article en

Abstract

Neurofibromatosis type 1 (NF1) is a common autosomal dominant neurocutaneous disorder with multisystem involvement. Although cutaneous and neural manifestations are frequent, vascular complications are relatively rare and often under-recognized. Spinal arteriovenous fistulas (AVFs) are an uncommon but important vascular manifestation of NF1 and may lead to progressive myelopathy due to venous hypertension and cord compression. We report a case of a 30-year-old male soldier presenting with gradually progressive spastic quadriparesis and sensory impairment caused by a cervical vertebral arteriovenous fistula associated with NF1. Successful endovascular embolization resulted in complete obliteration of the fistula and neurological stabilization. This case highlights the importance of early suspicion, detailed neuroimaging, and timely intervention in potentially reversible causes of myelopathy.

Zenodo (CERN European Organization for Nuclear Research)
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Vascular Malformations Diagnosis and Treatment
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