Levocarnitine improves cardiac energy metabolic remodeling in myocarditis mice
LC effectively improved myocardial metabolic remodeling and alleviated cardiac insufficiency in myocarditis. The underlying mechanism may involve LC-mediated suppression of the PI3K/Akt signaling pathway, potentially linked to increased expression of the key mitochondrial regulator PGC-1α.
Authors
- Bing He
- Xiang Xu
- Shutong Yang
- Xiaoou Li
- Zhenpeng Lu
- Zuzhen Guo
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Community Health Center (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fphar.2025.1706936
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Commission of Hubei Province