Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation
Our findings revealed a novel mechanism in which the STING-IRF7 pathway exacerbated endometrial inflammation and tissue damage by coordinately upregulating CD11b and activating the LCN2-ICAM-1 axis. Consequently, targeting the STING signaling pathway may offer a promising therapeutic strategy for chronic endometritis.
Authors
- Fengjuan Xing
- Hongchu Bao
- Zhan Song
- LI Liang
- Min Chu
- Ding Ma
Institutions
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1671848
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00