Efficacy of probiotics ( <i>Bifidobacterium bifidum</i> <scp>G9</scp> ‐1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open‐label, single‐arm study ( <scp>BIRDIE</scp>
Bifidobacterium bifidum improved stool form, defecation frequency, and quality of life of patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation, without worsening glycemic control and renal function.
Authors
- Yukiko Sugawara (ORCID: https://orcid.org/0000-0002-0506-2513)
- Hidenori YOSHII
- Daisuke Sugimoto (ORCID: https://orcid.org/0000-0003-0943-0712)
- Hiroaki Sato (ORCID: https://orcid.org/0000-0003-2558-9248)
- Fuki Ikeda (ORCID: https://orcid.org/0000-0002-7638-6056)
- Hirotsugu Uzawa
- Junko Sato
- Reina Muto
- Hirotaka Watada
- Yuya Nishida
Institutions
- Juntendo University (JP)
- Miwa Internal Medicine Clinic (JP)
- Juntendo University Urayasu Hospital (JP)
- Tokyo Metropolitan Geriatric Hospital (JP)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1111/jdi.70236
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- Sanofi
- Boehringer Ingelheim Japan
- Novo Nordisk
- Eli Lilly Japan
- Bayer Yakuhin
- Novo Nordisk Pharma