Pharmacokinetics of ampicillin, sulbactam and combined ampicillin/sulbactam in subcutis, muscle and plasma: A microdialysis trial in healthy volunteers
Although tissue concentrations almost reached plasma levels, the target attainment of ampicillin may be suboptimal when administered three times daily. Sulbactam tissue and plasma levels were slightly higher after combined administration with ampicillin than after administration of sulbactam alone.
Authors
- Marlene Prager (ORCID: https://orcid.org/0000-0002-7326-8310)
- Christoph Dorn (ORCID: https://orcid.org/0000-0002-2560-9598)
- Felix Bergmann (ORCID: https://orcid.org/0000-0002-1224-9036)
- Valentin al Jalali (ORCID: https://orcid.org/0000-0002-9196-1936)
- Maria Sanz-Codina (ORCID: https://orcid.org/0000-0002-1687-5296)
- Edith Lackner
- Theresa Pecho (ORCID: https://orcid.org/0009-0005-4629-9081)
- Anselm Jorda
- Lukas Schulz
- Amelie Leutzendorff
- Lena Pracher
- Markus Zeitlinger
Institutions
- University of Regensburg (DE)
- Medical University of Vienna (AT)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.ijantimicag.2026.107716
- Citations
- 2
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 65.15