Long-term outcomes and temporal trends following liver transplantation for chronic liver disease in the intensive care unit
This large national cohort study provides a comprehensive evaluation of long-term outcomes in critically ill patients with cirrhosis undergoing liver transplantation while in the intensive care unit. Despite advances in transplant care over the past decade, we observed a persistent survival gap in this high-risk population, primarily driven by increased mortality within the first year after transplantation. Age, the need for mechanical ventilation, and donor-related factors were independently associated with this excess risk. We also found no significant improvement in outcomes over time. These results underscore the continued need for refined candidate selection and donor allocation strategies, taking into account age, pre-transplant clinical stability, and graft quality to optimize post-transplant survival.
Authors
- Magdalena Meszaros (ORCID: https://orcid.org/0000-0002-5569-7285)
- J. Dumortier
- S. Dharancy
- Térésa Antonini (ORCID: https://orcid.org/0009-0005-0441-4547)
- François Faitot (ORCID: https://orcid.org/0000-0001-6514-0774)
- C. Duvoux
- Claire Pérignon
- C. Francoz
- GP Pageaux
- Claire Vanlemmens (ORCID: https://orcid.org/0000-0002-2048-3324)
- F. Conti
- Audrey Coilly
- Nassim Kamar
- Corinne Antoine
- Laure Elkrief
- Florent Artru
- Marie-Noelle Hilleret
- Pauline Houssel-Debry
- José Ursic-Bedoya
- Maryline Debette-Gratien
- Jean Hardwigsen
- Laurence Chiche
- Rodolphe Anty
- Armand Abergel
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Toulouse III - Paul Sabatier (FR)
- Inserm (FR)
- Université Paris-Est Créteil (FR)
- Université de Montpellier (FR)
- Hôpital Beaujon (FR)
- Sorbonne Université (FR)
- Hôpital de la Croix-Rousse (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Toulouse Mathematics Institute (FR)
- Hospices Civils de Lyon (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Hôpital Cardiologique du Haut-Lévêque (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Edouard Herriot (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Center for HIV and Hepatogastroenterology (DE)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Agence de la Biomédecine (FR)
- Hôpital Saint Eloi (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Hôpital Claude Huriez (FR)
- Institut pour l'avancée des biosciences (FR)
- Hôpital de la Timone (FR)
- Hôpital Paul-Brousse (FR)
- Université de Rennes (FR)
- Université de Strasbourg (FR)
- Université Grenoble Alpes (FR)
- Université de Franche-Comté (FR)
Publication Details
- Journal
- JHEP Reports
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101722
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université Grenoble Alpes
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Agence de la Biomédecine
- Hospices Civils de Lyon
- Assistance publique-Hôpitaux de Paris
- Centre Hospitalier Universitaire de Rennes