Assessment of histotripsy as a bone-sparing tumor ablation technique in ex vivo osteosarcoma tumor-affected limbs
Histotripsy preserves the mechanical integrity of both tumor-affected and normal bone. These results support histotripsy's potential as a non-invasive, bone-sparing, patient-specific therapeutic approach for clinical osteosarcoma.
Authors
- Preeya F. Achari
- Elliana Vickers (ORCID: https://orcid.org/0000-0003-2639-9470)
- Joanne Tuohy (ORCID: https://orcid.org/0000-0003-1516-3841)
- Eli Vlaisavljevich (ORCID: https://orcid.org/0000-0002-4097-6257)
- Lauren Ruger (ORCID: https://orcid.org/0000-0002-7291-4907)
- Caitlyn J. Collins
Institutions
- Carilion Roanoke Memorial Hospital (US)
- Virginia–Maryland College of Veterinary Medicine (US)
- Virginia Tech (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fvets.2025.1652469
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Focused Ultrasound Foundation
- National Institutes of Health
- National Center for Advancing Translational Sciences