Detecting the Undetectable: Analytical Strategies for Novel Psychoactive Substances

An integrated, adaptive analytical framework combining high-resolution mass spectrometry, ambient ionization, and AI-driven data analysis will help address the fast-evolving NPS landscape. Standardization of reference materials, harmonization across laboratories, and interdisciplinary collaboration between chemists, clinicians, and regulatory agencies will be key to improving the speed, sensitivity, and public health impact of NPS detection.

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Publication Details

Journal
Therapeutic Drug Monitoring
Published
2026-01-09
DOI
https://doi.org/10.1097/ftd.0000000000001431
Primary Topic
Forensic Toxicology and Drug Analysis
Type
article
Field-Weighted Citation Impact
0.00
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article

Detecting the Undetectable: Analytical Strategies for Novel Psychoactive Substances

Nicolas Védrenne, Franck Saint‐Marcoux, Pauline Griffeuille, Souleiman El Balkhi et al.
Therapeutic Drug Monitoring
Forensic Toxicology and Drug Analysis
article

Detecting the Undetectable: Analytical Strategies for Novel Psychoactive Substances

Nicolas Védrenne, Franck Saint‐Marcoux, Pauline Griffeuille, Souleiman El Balkhi, Elisa Jousselin, Isy Petit
article en

Abstract

An integrated, adaptive analytical framework combining high-resolution mass spectrometry, ambient ionization, and AI-driven data analysis will help address the fast-evolving NPS landscape. Standardization of reference materials, harmonization across laboratories, and interdisciplinary collaboration between chemists, clinicians, and regulatory agencies will be key to improving the speed, sensitivity, and public health impact of NPS detection.

Therapeutic Drug MonitoringVol. 48(2)
Inserm (FR), Université de Limoges (FR)
Clean water and sanitation
Openalex Percentile: Top 93%
Forensic Toxicology and Drug Analysis
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