Combined nandrolone and resistance training induced cardiac remodelling and oxidative stress despite enhanced cardiomyocyte contractility
ND combined with RT induced adverse cardiac remodeling and impaired ventricular function, despite enhanced cardiomyocyte contractility, and intensified molecular and oxidative disturbances, indicating a maladaptive cardiac response. This is the first study to demonstrate regional differences in contractility and redox balance of isolated ventricular cardiomyocytes under ND plus RT.
Authors
- Emily Correna Carlo Reis (ORCID: https://orcid.org/0000-0002-9794-6972)
- Antônio José Natali (ORCID: https://orcid.org/0000-0002-4927-4024)
- Carolina Camargos Rocha (ORCID: https://orcid.org/0009-0001-9185-0611)
- Luciano Bernardes Leite (ORCID: https://orcid.org/0000-0002-3012-1327)
- Pedro Zavagli Suarez (ORCID: https://orcid.org/0000-0001-5501-8556)
- Leandro Licursi de Oliveira (ORCID: https://orcid.org/0000-0003-4353-7011)
- Edilamar Menezes de Oliveira (ORCID: https://orcid.org/0000-0002-7101-312X)
- Arthur Eduardo de Carvalho Quintão
- Alexa Alves de Moraes
- Miguel Araujo Carneiro-Júnior
- Sebastião Felipe Ferreira Costa
- Leôncio Lopes Soares
- Pedro Forte
- Beatriz Lana Fontes
Institutions
- Universidade Federal de Viçosa (BR)
- Universidade de São Paulo (BR)
- Universidade Politécnica de Bragança (PT)
- Instituto dos Vinhos do Douro e Porto (PT)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1371/journal.pone.0340574
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00