Immunoprofiling by CyTOF Uncovers Disease-Defining Peripheral Immune Signatures and Mechanistic Links to Renal Injury in IgA Nephropathy
Our study delineates a peripheral immune signature of IgAN characterized by enhanced B-cell activation and cytotoxic T-cell responses, reflecting a dual-axis immune imbalance that may shape disease progression. These findings refine current immunopathogenic models and may guide future therapeutic research.
Authors
- Su-Fang Shi
- Ting Gan (ORCID: https://orcid.org/0000-0003-1813-8369)
- Ji-Cheng Lv
- Shu Qu (ORCID: https://orcid.org/0009-0007-7918-9166)
- Jiawei He
- Hong Zhang
- Xu-jie Zhou
- Li-jun Liu
- Xin Wang
Institutions
- Peking University (CN)
- Precision for Medicine (United States) (US)
- Peking University First Hospital (CN)
Publication Details
- Journal
- Kidney Diseases
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1159/000550337
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Peking University First Hospital
- National Natural Science Foundation of China
- Peking University
- National Key Research and Development Program of China