19 02 Metastasis Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

High-Grade Serous Ovarian Carcinoma (HGSC) exhibits a unique metastatic pattern fundamentally differentfrom other solid tumors: rather than hematogenous dissemination to distant organs, HGSC primarily spreadsthrough transcoelomic seeding within the peritoneal cavity, with secondary colonization of lung, liver, andlymph nodes. The ER-like subset of HGSC displays distinct metabolic characteristics, including lipid/glutaminedependence and estrogen receptor expression, creating specialized adaptation requirements for each metastaticniche.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-07
DOI
https://doi.org/10.5281/zenodo.18167926
Primary Topic
Ovarian cancer diagnosis and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

19 02 Metastasis Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Ovarian cancer diagnosis and treatment
article

19 02 Metastasis Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type

Ionut Alexandru Stefan
article en

Abstract

High-Grade Serous Ovarian Carcinoma (HGSC) exhibits a unique metastatic pattern fundamentally differentfrom other solid tumors: rather than hematogenous dissemination to distant organs, HGSC primarily spreadsthrough transcoelomic seeding within the peritoneal cavity, with secondary colonization of lung, liver, andlymph nodes. The ER-like subset of HGSC displays distinct metabolic characteristics, including lipid/glutaminedependence and estrogen receptor expression, creating specialized adaptation requirements for each metastaticniche.

Zenodo (CERN European Organization for Nuclear Research)
Life in Land
Openalex Percentile: Top 94%
Ovarian cancer diagnosis and treatment
DOIOpen Access PDFOpenAlex
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19 02 Metastasis Base Architecture Ovarian Carcinoma HGSC BRCA-wild-type — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS