Parsing Specificity in Psychiatric Polygenic Scores—What the p-Factor Adds and What It Does Not

confront a central ambiguity in psychiatric genetics.They ask, how much of what polygenic scores (PGSs) estimate is associated with disorder-specific risk vs a transdiagnostic general factor of psychopathology (p)?This latent dimension, estimated with genomic structural equation modeling (genomic SEM), captures shared genetic liability across disorders and is analogous to the g Open Access.