Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network Study
This hypothesis-generating study identified several potential signals (blood pressure status, lipid status, obesity status, and sex) where there exists treatment effect heterogeneity for several classes of type 2 diabetes mellitus drugs. These preliminary findings highlight the potential for personalized type 2 diabetes mellitus treatment recommendations based on patient characteristics.
Authors
- Thomas Falconer (ORCID: https://orcid.org/0000-0001-6904-1394)
- Hsin Yi Chen (ORCID: https://orcid.org/0000-0002-7907-2335)
- Marc A. Suchard (ORCID: https://orcid.org/0000-0001-9818-479X)
- Xinzhuo Jiang (ORCID: https://orcid.org/0000-0002-1944-6526)
- Ruochong FAN
- Hannah Morgan‐Cooper
- David Davila-Garcia
- George Hripcsak
- Anna Ostropolets
- Tara V Anand
- Linying Zhang
Institutions
- Johnson & Johnson (United States) (US)
- University of California, Los Angeles (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- Stanford Health Care (US)
- Department of Veterans Affairs (AU)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-08
- DOI
- https://doi.org/10.64898/2026.01.06.26343548
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00