L-type amino acid transporter 1 deficiency delays intestinal tissue repair in dextran sulfate sodium-induced colitis
LAT1 deficiency in the intestinal epithelium delays tissue repair by impairing colonic crypt regeneration. Our findings offer insights into how nutrient availability in the tissue environment is sensed by cells and may influence the control of colonic tissue recovery from inflammatory damage.
Authors
- Namiko Hoshi (ORCID: https://orcid.org/0000-0003-2768-3991)
- Makoto Ooi (ORCID: https://orcid.org/0000-0002-8238-7792)
- Ryuichi Ohgaki (ORCID: https://orcid.org/0000-0002-6894-7239)
- Haruka Miyazaki (ORCID: https://orcid.org/0000-0001-5155-0086)
- Norihiro Okamoto
- Yuna Ku (ORCID: https://orcid.org/0000-0003-3227-2556)
- Yuan Sui (ORCID: https://orcid.org/0009-0005-0917-1847)
- Yuzo Kodama
- Yoshikatsu Kanai
- Hui Yang
- Misaki Agawa
- Daisuke Watanabe
- Hirotaka Nakamura
- Yuta Inoue
- Yoshihiko Yano
Institutions
- Kobe University (JP)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1016/j.intimp.2025.116138
- Primary Topic
- Amino Acid Enzymes and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00