Highly Speculative Single cell RNA seq show the microreziduu in FISS is not homogenuus

I propose that FISS microresidual populations post-surgery are not phenotypically homogeneous but exist as threedistinct, dynamically interconvertingcellularstates: (1)Proliferative (mitoticallyactive, integrin-dependent), (2) Invasive (matrixdegrading,EMT-associated),and(3)Quiescent(metabolicallydormant,therapy-resistant).Furthermore,Ihypothesizethattherelativeproportionsofthesestatesshifttemporallypostoperatively, drivenbyevolvingwoundbedmicroenvironmental gradients (growth factors,ECMmaturation,metabolicstress).

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-05
DOI
https://doi.org/10.5281/zenodo.18155852
Primary Topic
Single-cell and spatial transcriptomics
Type
article
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article

Highly Speculative Single cell RNA seq show the microreziduu in FISS is not homogenuus

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Single-cell and spatial transcriptomics
article

Highly Speculative Single cell RNA seq show the microreziduu in FISS is not homogenuus

Ionut Alexandru Stefan
article en

Abstract

I propose that FISS microresidual populations post-surgery are not phenotypically homogeneous but exist as threedistinct, dynamically interconvertingcellularstates: (1)Proliferative (mitoticallyactive, integrin-dependent), (2) Invasive (matrixdegrading,EMT-associated),and(3)Quiescent(metabolicallydormant,therapy-resistant).Furthermore,Ihypothesizethattherelativeproportionsofthesestatesshifttemporallypostoperatively, drivenbyevolvingwoundbedmicroenvironmental gradients (growth factors,ECMmaturation,metabolicstress).

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 94%
Single-cell and spatial transcriptomics
DOIOpen Access PDFOpenAlex
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Highly Speculative Single cell RNA seq show the microreziduu in FISS is not homogenuus — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS