Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

The proposed multidimensional embedded feature selection framework showed strong diagnostic performance and interpretability in identifying key biomarkers for RA, effectively addressing the issue of indicator redundancy and enhancing diagnostic precision. This pragmatic application of an established GBDT+LR framework, integrated with SHAP for interpretability and built on routine clinical data, offers potential clinical utility in RA diagnosis.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-09
DOI
https://doi.org/10.3389/fimmu.2025.1679223
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
Field-Weighted Citation Impact
0.00
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article

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

Chunpu Qu, Qiang Zhang, Zhenqiang Huang, Jiaqi Chen
Frontiers in Immunology
Rheumatoid Arthritis Research and Therapies
article

Research on key indicators for diagnosis and prediction of rheumatoid arthritis based on GBDT+LR embedded feature selection model

Chunpu Qu, Qiang Zhang, Zhenqiang Huang, Jiaqi Chen
article en

Abstract

The proposed multidimensional embedded feature selection framework showed strong diagnostic performance and interpretability in identifying key biomarkers for RA, effectively addressing the issue of indicator redundancy and enhancing diagnostic precision. This pragmatic application of an established GBDT+LR framework, integrated with SHAP for interpretability and built on routine clinical data, offers potential clinical utility in RA diagnosis.

Frontiers in ImmunologyVol. 16
Lishui University (CN), Lishui Central Hospital (CN), Lishui City People's Hospital (CN)
Reduced inequalities
Openalex Percentile: Top 94%
Rheumatoid Arthritis Research and Therapies
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