Plasma Aβ42/Aβ40 determined by mass spectrometry is associated with longitudinal changes in amyloid accumulation, brain atrophy, and conversion to mild cognitive impairment due to Alzheimer’s disease in individuals with subjective cognitive decline:
Our findings suggest that the plasma Aβ42/Aβ40 ratio is associated with future amyloid accumulation, brain atrophy, and conversion to prodromal AD in individuals with SCD. This biomarker may help characterize individuals with a higher likelihood of progression and could support earlier and more personalized strategies.
Authors
- Noelia Fandos
- J. Terencio
- José Antonio Allué (ORCID: https://orcid.org/0000-0002-5690-3618)
- Marta Marquié
- Leticia Sarasa
- M.A. Tejero
- A. Muñoz-Morales
- F. Lomeña
- P. Sanz-Cartagena
- A. Vivas
- B. Calm-Salvans
- A. Stephens
- P. Cañabate
- J.N. Rodríguez
- C. Cuevas
- A. Orellana
- Mª Eugenia Sáez
- M.I. Ramis
- N. Roé-Vellvé
- Ángela Sanabria
- M. Torres
- E. Martín
- R. Puerta
- C. Olivé
- M. Buendia
- A. Perissinotti
- Miren Jone Gurruchaga
- M. Berthier
- A.B. Nogales
- María Pascual-Lucas
- Xavier Montalban
- S. Diego
- A. Lafuente
- Lluís Tárraga
- C. Martínez
- F. Campos
- V. Pérez-Grijalba
- A. Solivar
- J. Blázquez-Folch
- A. Niñerola
- M. Pascual-Lucas
- J.M. Escudero
- A. Pancho
- M. L. Moreno
- I. de Rojas
- A. Miguel
- M. Martínez
- J.A. Alllué
- S. Seguer
- M. Ibarria
- M. Alegret
- M.V. Fernández
- M. Boada
- P. Bayón-Bujan
- Amanda Cano
- Mercè Boada
- Oscar Sotolongo-Grau
- L. Tárraga
- O. Sotolongo-Grau
- A. Pérez-Cordon
- M. Rosende-Roca
- Agustín Ruíz
- G. Domingues-Kolinger
- G. Ortega
- J.P. Tartari
- M. Guitart
- E. Pelejà
- E. Pérez-Martínez
- L. Montrreal
- A. Gailhajenet
- A. Cano
- A. Espinosa
- S. Preckler
- M. Gómez-Chiari
- S. Bullich
- L. Vargas
- A. Páez
- N. Aguilera
- J. Terencio
- N. Fandos
- L. Cañada
- J. Giménez
- F. Casales
- S. Valero
- A. Morera
- N. Muñoz
- P.C. Gutiérrez
- A. Sanabria
- A. Ruiz
- J. Romero
- M. Marquié
- I. Hernández
- E. Alarcón-Martín
- M.J. Gurruchaga
- L. Sarasa
- P. García-González
- L. Núñez
- A. Valenzuela
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- Meta (Israel) (IL)
- Instituto de Salud Carlos III (ES)
- Fundacion Agencia Aragonesa para la Investigacion y el Desarrollo (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Sociedad Anónima Industrias Celulosa Aragonesa (Spain) (ES)
- Fundació ACE (ES)
- Grifols (Spain) (ES)
Publication Details
- Journal
- The Journal of Prevention of Alzheimer s Disease
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.tjpad.2025.100465
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00