DNA Methylation-mediated BTN3A2 Regulation via CD14+CD16+ Monocytes Protects Against Primary Sclerosing Cholangitis
These findings identify BTN3A2 as a causal protective factor in PSC, mediated by DNA methylation and CD14+CD16+ monocyte-driven immunity, highlighting its therapeutic potential for precision medicine.
Authors
- Haitao Wang (ORCID: https://orcid.org/0009-0004-3423-7652)
- Chao Chen (ORCID: https://orcid.org/0000-0003-1703-6483)
- Yixin Xu
- Kun Wang
- Jie Zhou
Institutions
- Jiangsu University (CN)
- Xuzhou Medical College (CN)
- Soochow University (CN)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2026-01-06
- DOI
- https://doi.org/10.2174/0115680266423650251031072305
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00