Multicentric Reticulohistiocytosis: A Report of Two Cases

Multicentric reticulohistiocytosis (MRH) is a rare histiocytic disorder with cutaneous and joint manifestations that most commonly affect middle-aged women. It is often misidentified as more common arthropathies and skin conditions, such as rheumatoid arthritis, dermatofibromas, progressive nodular histiocytomas, gouty tophi, and sarcoidosis, leading to incorrect treatment approaches. Here, we report two cases of MRH, diagnosed based on clinical and histopathological findings, who showed a significant response with the treatment of weekly methotrexate and tapering oral steroids.