Investigating the neuroprotective effect of heparin in improving mitochondrial function in rats with cardiac arrest cardiopulmonary resuscitation based on transcriptome sequencing
Heparin provided neuroprotection after CA-CPR by ameliorating mitochondrial dysfunction via multi-target regulation of key genes (Epsa1, Idh2, and Hif3a), enhancing energy metabolism, reducing oxidative stress, and inhibiting hyperactivated coagulation-inflammation cascades. These findings highlight heparin's potential as an adjunctive therapy for improving neurological outcomes post-resuscitation.
Authors
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Ningkang Li (ORCID: https://orcid.org/0000-0001-7561-3854)
- Yang Gu (ORCID: https://orcid.org/0000-0002-9277-2846)
- Biyun Tian
- Yan Li
- Xin Liu
- Qingshan Ye
- Xiaohong Zhou
Institutions
- Ningxia Hui Autonomous Region Peoples Hospital (CN)
- Bay Area Hospital (US)
- Ningxia Medical University (CN)
- The Fourth People's Hospital of Ningxia Hui Autonomous Region (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fmed.2025.1712265
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ningxia Medical University
- Natural Science Foundation of Ningxia Province