Characteristics and management of asthma from China Asthma Data Registry Project (CHART)

Background There is limited information available on patients with asthma in hospitals in China. We investigated their clinical and phenotypic characteristics and management. Methods The CH ina A sthma Data R egistry Projec T (CHART) study is a multicenter, hospital-based, prospective, observational study in which patients were recruited from outpatient clinics. This analysis used baseline cross-sectional data from patients with asthma (≥12 years) enrolled at 58 tertiary hospitals in China between March 25, 2018, and July 11, 2019. Results A total of 20,683 patients with asthma (56.2% female, 15.0% patients with active tobacco use) were enrolled. A total of 22.8% had uncontrolled asthma, 39.5% had partially controlled asthma, and 45.3% experienced ≥1 exacerbation annually, including 31.7% who required hospitalization, with only 21.4% having previously used inhaled corticosteroids (ICSs) in the past year. Cough (80.0%) was the most common symptom, followed by wheezing (70.7%), with 14.6% having cough-predominant asthma and 11.4% having cough-variant asthma. Multivariate logistic regression revealed that cough severity independently predicted poor control, irrespective of airflow limitation or inflammatory status, with stronger associations in ICS users than in nonusers, with a visual analogue scale (VAS) score ≥40 (aOR: 3.88–5.47 versus 2.49–2.94), a cough evaluation test (CET) score ≥12 (aOR: 11.15–20.91 versus 3.97–5.55), and a Leicester Cough Questionnaire (LCQ) score <15 (aOR: 6.15–13.66 versus 2.45–3.18). Conclusions We found significant suboptimal control, a high prevalence of cough-related phenotypes, frequent exacerbations, and hospital admissions in patients with asthma attending hospitals. This underscores the need to prioritize the assessment and treatment of cough in asthma.

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Journal
ERJ Open Research
Published
2026-01-08
DOI
https://doi.org/10.1183/23120541.01158-2025
Primary Topic
Asthma and respiratory diseases
Type
article
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article

Characteristics and management of asthma from China Asthma Data Registry Project (CHART)

Xianwei Ye, Kefang Lai, Qiaojie He, Meiling Jin et al.
ERJ Open Research
Asthma and respiratory diseases
article

Characteristics and management of asthma from China Asthma Data Registry Project (CHART)

Xianwei Ye, Kefang Lai, Qiaojie He, Meiling Jin, ChunTao Liu, Chen Qiu, Liping Chen, Shen Hh, Bin Xing, Feng Wu, Chong Bai, M Y Jiang, Xianming Fan, Xinming Su, Fang Yi, Xin Zhou, Changzheng Wang, Guangfa Wang, Tingting Xu, Nanshan Zhong, Xiujuan Geng, Kian Fan Chung, Mingjuan Zhou, Rongchang Chen, Xiuqing Liao, Jianping Zhao, Guochao Shi, Baoan Gao, Ping Chen, Yunhui Zhang
article en

Abstract

Background There is limited information available on patients with asthma in hospitals in China. We investigated their clinical and phenotypic characteristics and management. Methods The CH ina A sthma Data R egistry Projec T (CHART) study is a multicenter, hospital-based, prospective, observational study in which patients were recruited from outpatient clinics. This analysis used baseline cross-sectional data from patients with asthma (≥12 years) enrolled at 58 tertiary hospitals in China between March 25, 2018, and July 11, 2019. Results A total of 20,683 patients with asthma (56.2% female, 15.0% patients with active tobacco use) were enrolled. A total of 22.8% had uncontrolled asthma, 39.5% had partially controlled asthma, and 45.3% experienced ≥1 exacerbation annually, including 31.7% who required hospitalization, with only 21.4% having previously used inhaled corticosteroids (ICSs) in the past year. Cough (80.0%) was the most common symptom, followed by wheezing (70.7%), with 14.6% having cough-predominant asthma and 11.4% having cough-variant asthma. Multivariate logistic regression revealed that cough severity independently predicted poor control, irrespective of airflow limitation or inflammatory status, with stronger associations in ICS users than in nonusers, with a visual analogue scale (VAS) score ≥40 (aOR: 3.88–5.47 versus 2.49–2.94), a cough evaluation test (CET) score ≥12 (aOR: 11.15–20.91 versus 3.97–5.55), and a Leicester Cough Questionnaire (LCQ) score <15 (aOR: 6.15–13.66 versus 2.45–3.18). Conclusions We found significant suboptimal control, a high prevalence of cough-related phenotypes, frequent exacerbations, and hospital admissions in patients with asthma attending hospitals. This underscores the need to prioritize the assessment and treatment of cough in asthma.

ERJ Open Research
Shenyang Medical College (CN), Guangzhou University of Chinese Medicine (CN), Second Military Medical University (CN), Zunyi Medical University (CN), Shanghai Jiao Tong University (CN), Dalian Medical University (CN), Peking University (CN), Sichuan University (CN), Fudan University (CN), Renji Hospital (CN), China-Japan Friendship Hospital (CN), Harefield Hospital (GB), Affiliated Hospital of Southwest Medical University (CN), Xian Central Hospital (CN), West China Hospital of Sichuan University (CN), First People's Hospital of Yunnan Province (CN), Royal Brompton Hospital (GB), First Affiliated Hospital of Guangzhou Medical University (CN), Second Affiliated Hospital of Dalian Medical University (CN), ShenZhen People’s Hospital (CN), Guangdong Provincial Hospital of Traditional Chinese Medicine (CN), Changhai Hospital (CN), Xinqiao Hospital (CN), Fuling Center Hospital of Chongqing (CN), Zhongshan Hospital (CN), General Hospital of Shenyang Military Region (CN), Peking University First Hospital (CN), Huizhou Central People's Hospital (CN), First Hospital of China Medical University (CN), Yichang Central People's Hospital (CN), Guizhou Provincial People's Hospital (CN), Second Affiliated Hospital of Zhejiang University (CN), Tongji Hospital (CN), Anshan Hospital (CN), China Medical University (CN), Guangzhou Medical University (CN), Huizhou University (CN)
Good health and well-being
Openalex Percentile: Top 94%
Asthma and respiratory diseases
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