Rapid Induction of Remission With Upadacitinib Followed by Cytomegalovirus Colitis in a Hospitalized Patient With Crohn's Disease
A 60-year-old woman with acute severe Crohn's colitis had a rapid initial response to off-label, high-intensity upadacitinib; however, she subsequently demonstrated clinical deterioration ultimately undergoing colectomy for suspected refractory Crohn's disease. Surgical pathology unexpectedly revealed quiescent Crohn's disease with cytomegalovirus colitis, despite no initial endoscopic evidence of infection.
Authors
- John D. Byrn
- Anastasia Wasylyshyn (ORCID: https://orcid.org/0009-0000-9939-0106)
- Shrinivas Bishu
- Asma Nusrat
- Abhishek Satishchandran (ORCID: https://orcid.org/0000-0002-0330-3176)
- Rutwik Pradeep Sharma
- Andrea Todisco (ORCID: https://orcid.org/0000-0002-7232-8780)
- Syed Adeel Hassan
- Gal Hodish
- Reid Herran
- Samuel Wilcox
- Haley Mertens
- Jeffrey A. Berinstein
- Peter D.R. Higgins
Institutions
- Sparrow Health System (US)
- University of Michigan (US)
Publication Details
- Journal
- ACG Case Reports Journal
- Published
- 2026-01-01
- DOI
- https://doi.org/10.14309/crj.0000000000001961
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00