Prolonged survival in EGFR exon 20 insertion mutant lung adenocarcinoma: case report of sequential osimertinib and furmonertinib with research trend analysis

Sequential high-dose third-generation EGFR-TKIs may offer clinically meaningful benefit in selected EGFR ex20ins cases; however, this strategy remains non-standard and should be regarded as hypothesis-generating, warranting further prospective evaluation.

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Publication Details

Journal
Frontiers in Medicine
Published
2026-01-09
DOI
https://doi.org/10.3389/fmed.2025.1677737
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Prolonged survival in EGFR exon 20 insertion mutant lung adenocarcinoma: case report of sequential osimertinib and furmonertinib with research trend analysis

Abdullah Al-Danakh, Haijing Liu, Ning Wang, Yishan Lu et al.
Frontiers in Medicine
Lung Cancer Treatments and Mutations
article

Prolonged survival in EGFR exon 20 insertion mutant lung adenocarcinoma: case report of sequential osimertinib and furmonertinib with research trend analysis

Abdullah Al-Danakh, Haijing Liu, Ning Wang, Yishan Lu, Ruiguo Zhao, Jingjing Zhao, Ping Gao, Nana Huang
article en

Abstract

Sequential high-dose third-generation EGFR-TKIs may offer clinically meaningful benefit in selected EGFR ex20ins cases; however, this strategy remains non-standard and should be regarded as hypothesis-generating, warranting further prospective evaluation.

Frontiers in MedicineVol. 12
Central South University (CN), Dalian Medical University (CN), Liaoning University of Traditional Chinese Medicine (CN), Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN), First Affiliated Hospital of Dalian Medical University (CN), Xiangya Hospital Central South University (CN), Amran University (YE), Liaoning Cancer Hospital & Institute (CN)
Good health and well-being
Openalex Percentile: Top 94%
Lung Cancer Treatments and Mutations
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