Jagged2-Notch axis: keeping stem cells in asymmetric balance

In this issue of Blood, Matteini et al 1 demonstrate that age-associated loss of Jagged2 (J2) expression by bone marrow endothelial cells (BMECs) impairs hematopoietic stem cell (HSC) polarity, asymmetric cell division (ACD), and regenerative potential by promoting cis inhibition of Notch signaling during aging.

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Publication Details

Journal
Blood
Published
2026-01-08
DOI
https://doi.org/10.1182/blood.2025031619
Primary Topic
Developmental Biology and Gene Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Jagged2-Notch axis: keeping stem cells in asymmetric balance

Nadia Carlesso
Blood
Developmental Biology and Gene Regulation
article

Jagged2-Notch axis: keeping stem cells in asymmetric balance

Nadia Carlesso
article en

Abstract

In this issue of Blood, Matteini et al 1 demonstrate that age-associated loss of Jagged2 (J2) expression by bone marrow endothelial cells (BMECs) impairs hematopoietic stem cell (HSC) polarity, asymmetric cell division (ACD), and regenerative potential by promoting cis inhibition of Notch signaling during aging.

BloodVol. 147(2)
City of Hope (US), Beckman Research Institute
Openalex Percentile: Top 94%
Developmental Biology and Gene Regulation
DOIOpen Access PDFOpenAlex
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Jagged2-Notch axis: keeping stem cells in asymmetric balance — Nadia Carlesso · Blood (2026) | TGRS Research Map | TGRS