CA9+ cancer-associated fibroblasts cooperate with SPP1+ tumor-associated macrophages driving immune resistance in triple-negative breast cancer
This study unveils the critical immunosuppressive axis orchestrated by CA9+CAF and SPP1+TAM in TNBC, offering novel insights into the stromal regulatory mechanisms driving immune resistance. The cell-to-cell interaction signature holds promise as predictor of immunotherapy response and potential therapeutic target.
Authors
- Qian Jiang (ORCID: https://orcid.org/0000-0001-7131-0522)
- Qin Ma
- Jing Wang
Institutions
- Shanxi Provincial Cancer Hospital (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1007/s00018-025-06056-2
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 24.43