Cortical activation and functional connectivity between healthy elderly and Parkinson’s disease patients and between cognitive subgroups of Parkinson’s patients: a multichannel functional near-infrared spectroscopy study

Our findings generate the hypothesis that PD is associated with altered neurovascular responses and disrupted cortical network organization in the frontal and temporal lobes, especially in cognitively impaired subgroups. These results support the potential utility of fNIRS for characterizing cognition-related neural alterations in PD and provide a basis for future hypothesis-driven and longitudinal investigations.