A proteomics-based study on the mechanisms of Terminalia chebula Retz processed Aconitum kusnezoffii Reichb against rheumatoid arthritis and its cardiotoxicity reduction

HC exerts its anti-RA effects by prolonging the retention time of anti-inflammatory components in the body, reducing the expression of Ctsk, Acp5, and Casp3 proteins, and inhibiting bone erosion and joint damage; it also reduces cardiac toxicity by reducing oxidative stress and protecting against apoptosis, thereby forming a multidimensional detoxification mechanism. This study focused on the anti-inflammatory activity of HC, integrating blood component analysis, cardiac tissue distribution detection, and disease model-driven synovial and cardiac proteomics analysis to scientifically elucidate the detoxification and efficacy principles of HC, providing new strategies for comprehensive research on detoxification and efficacy in the preparation of toxic herbs for ethnic minorities.