Humidity impacts volatile anesthetic and heat responses of malignant hyperthermia susceptible mice
Absolute humidity was associated with worsened outcomes during heat and isoflurane exposure in male MHS mice and an increase in MH occurrence in male MHS patients. These results support maintaining humidity levels within operating suites at lower levels of current guidelines, especially where dantrolene is not available.
Authors
- Anna Hellblom (ORCID: https://orcid.org/0000-0002-4455-6401)
- Nicol Cornelia Voermans (ORCID: https://orcid.org/0000-0002-5837-7295)
- Sheila Riazi (ORCID: https://orcid.org/0000-0002-0670-1516)
- Heinz Jungbluth (ORCID: https://orcid.org/0000-0002-7159-3427)
- Gunilla Islander (ORCID: https://orcid.org/0000-0002-3137-0157)
- Robert T. Dirksen (ORCID: https://orcid.org/0000-0002-3182-1755)
- Robyn Gillies
- Luuk R. van den Bersselaar
- Miao He
- Sultan Temurziev
Institutions
- The Royal Melbourne Hospital (AU)
- University Health Network (CA)
- Radboud University Nijmegen (NL)
- King's College London (GB)
- Lund University (SE)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- University of Rochester Medical Center (US)
- Antwerp University Hospital (BE)
- Canisius-Wilhelmina Ziekenhuis (NL)
- Skåne University Hospital (SE)
Publication Details
- Journal
- Skeletal Muscle
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1186/s13395-025-00411-4
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health