Cobalt-Catalyzed C–H Activation/Annulation of <i>N</i> -(Naphthalen-1-yl)amides with Isocyanides: Synthesis of Benzo[ <i>c,d</i> ]indol-2-imines
This study unveils the first cobalt-catalyzed picolinamide-directed C-H/N-H annulation of <i>N</i>-(naphthalen-1-yl)picolinamide with isocyanides, which efficiently forms benzo[<i>c,d</i>]indol-2-imines via peri-C-H activation. Using Ag<sub>2</sub>O and mild conditions, it offers a cost-effective, atom-economical route with a broad substrate scope and in situ directing group removal for simplified synthesis and good yields.
Authors
- Mahesh Sonawane
- Raj N. Patel (ORCID: https://orcid.org/0000-0003-1634-1208)
- S. P. Ghosh
Institutions
- Central Salt and Marine Chemicals Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-01-09
- DOI
- https://doi.org/10.1021/acs.joc.5c02937
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00