Serological evidence of continued exposure to Plasmodium falciparum among residents in a near-elimination setting
This study reveals substantial micro-epidemiological variation in naturally acquired immunity to blood-stage malaria antigens in a pre-elimination setting. PfRh5 demonstrated universally strong immunogenicity across transmission intensities, whereas PfEBA175 exhibited heterogeneous responses reflecting focal exposure shaped by behavioral and environmental factors. These complementary patterns may inform multi-antigen vaccine strategies, village-specific interventions in areas with residual malaria transmission, and sero-surveillance development.
Authors
- Nuruliarizki Shinta Pandupuspitasari (ORCID: https://orcid.org/0000-0001-8300-4231)
- Ni Kadek Dita Cahyani (ORCID: https://orcid.org/0000-0003-4484-6414)
- Edo Yungki Saputra (ORCID: https://orcid.org/0009-0004-7782-0696)
- Derico Hitipeuw (ORCID: https://orcid.org/0009-0000-3200-0142)
- Mohd. Fadzil Daud
- Fadhila Fitriana
- Aprillia Andika Rahayu
- Raisha Nuranindita (ORCID: https://orcid.org/0009-0004-3512-6508)
- Fariha Akmalina Amirudin
- Fauzi Muh
- Jadidan Hada Syahada
- Bo-Young Jeon
- Jin-Hee Han
- M. Ilyas
Institutions
- Diponegoro University (ID)
- Kangwon National University (KR)
- Yonsei University (KR)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-01-09
- DOI
- https://doi.org/10.3389/fmicb.2025.1742072
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Korea Disease Control and Prevention Agency
- National Research Foundation
- National Research Foundation of Korea
- Universitas Diponegoro
- Lembaga Penelitian dan Pengabdian Kepada Masyarakat
- Ministry of Science and ICT, South Korea