08 02 Metastasis Base Architecture Esophageal Squamous Cell Carcinoma ESCC

Esophageal squamous cell carcinoma (ESCC) exhibits distinct metastatic patterns withsite-specific biomechanical adaptations: lymph node (65-75% incidence), lung (25-35%), liver(15-22%), and bone (12-18%). I present a mathematical framework quantifying Corelated evolution, metabolic flux networks, and critical vulnerabilities across these four major metastatic sites.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-01-06
DOI
https://doi.org/10.5281/zenodo.18164580
Primary Topic
Mathematical Biology Tumor Growth
Type
article
Field-Weighted Citation Impact
0.00
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article

08 02 Metastasis Base Architecture Esophageal Squamous Cell Carcinoma ESCC

Ionut Alexandru Stefan
Zenodo (CERN European Organization for Nuclear Research)
Mathematical Biology Tumor Growth
article

08 02 Metastasis Base Architecture Esophageal Squamous Cell Carcinoma ESCC

Ionut Alexandru Stefan
article en

Abstract

Esophageal squamous cell carcinoma (ESCC) exhibits distinct metastatic patterns withsite-specific biomechanical adaptations: lymph node (65-75% incidence), lung (25-35%), liver(15-22%), and bone (12-18%). I present a mathematical framework quantifying Corelated evolution, metabolic flux networks, and critical vulnerabilities across these four major metastatic sites.

Zenodo (CERN European Organization for Nuclear Research)
Openalex Percentile: Top 94%
Mathematical Biology Tumor Growth
DOIOpen Access PDFOpenAlex
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08 02 Metastasis Base Architecture Esophageal Squamous Cell Carcinoma ESCC — Ionut Alexandru Stefan · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS