Multiple myeloma risk linked to DNA damage response genes
Our results suggest expansion of the phenotypic spectrum of some of these DDRG to include MM. The identification of these germline predisposition genes opens the avenue for targeted screening of higher risk individuals especially those with young-onset or a family history of plasma cell gammopathies.
Authors
- E. Kim
- S. Slager
- Saad Z. Usmani (ORCID: https://orcid.org/0000-0002-5484-8731)
- Aaron D. Norman (ORCID: https://orcid.org/0000-0002-4208-2708)
- Lauren Gabriele Banaszak (ORCID: https://orcid.org/0000-0002-7682-0350)
- Michael Conry (ORCID: https://orcid.org/0000-0003-1904-8947)
- Linda Banovic Baughn (ORCID: https://orcid.org/0000-0001-5229-4897)
- Yelena M. Kemel (ORCID: https://orcid.org/0000-0002-5042-5651)
- Irina Ostrovnaya (ORCID: https://orcid.org/0000-0003-1783-0070)
- Brian J. Avery (ORCID: https://orcid.org/0000-0003-0611-8141)
- Nicola J. Camp (ORCID: https://orcid.org/0000-0002-4788-1998)
- Nicholas Boddicker (ORCID: https://orcid.org/0000-0002-6784-2072)
- Victoria Groner
- Sita Dandiker (ORCID: https://orcid.org/0000-0003-3837-7690)
- D. W. Sborov
- CM Vachon
- Vijai Joseph
- Shaleen Kumar
- Saloni Sinha
- Kenneth Offit
- Elizabeth E. Brown
- Kylee Maclachlan
- Parameshwaran Hari
- Mitul Waghmare
- Judy Garber
- Alyssa Clay-Gilmour
- Michelle Hildebrandt
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of South Carolina (US)
- Medical College of Wisconsin (US)
- Cornell University (US)
- Huntsman Cancer Institute (US)
- University of Alabama at Birmingham (US)
- St. Joseph's University New York (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Journal of Hematology & Oncology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s13045-025-01776-1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00